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Content provided by Jon Lund
Clinical Associate Professor, School of Graduate Entry Medicine & Health, University of Nottingham
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ULCERATIVE COLITIS versus CROHN'S DISEASE
ULCERATIVE COLITIS versus CROHN'S DISEASE
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CROHN's
| ULCERATIVE COLITIS
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| DISTRIBUTION
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| Location
| From mouth to anus |
Confined to the colon |
| Colonic
| Colonic involvement right sided usually |
Colonic involvement left sided |
| Rectum
| Seldom involved |
Commonly |
| Anus
| Fissures, Fistulas and abscesses common |
Anus rarely involved |
| PATHOLOGY
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| Macroscopic
| Patchy, segmental areas of inflammation, discrete ulcerations separated by segments of normal appearing mucosa - "skip" lesions |
Continuous uninterrupted inflammation from rectum proximally |
| Fistulae
| Common |
Seldom |
| Stenosis
| Common |
Seldom |
| Microscopic
| Trasmural inflammation with granuloma formation. Few crypt abscesses. |
Inflammation confined to mucosa. Granulomas rarely seen. Crypt abscesses multiple. |
| SMOKING
| Higher risk |
Lower risk |
| CURE
| Not usually cured by bowel resection |
Cured by colectomy |
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